@article{Sarkar_Mishra_Mishra_Gupta_Solanki_2018, title={TECHNOLOGY DVELOPMENT FOR POLYMER MODIFICATION TO ENHANCE SOLUBILITY OF POORLY SOLUBLE DRUG}, volume={1}, url={https://ijdra.com/index.php/journal/article/view/103}, DOI={10.22270/ijdra.v1i1.103}, abstractNote={<p>Solubilization of poorly soluble drugs is a frequently encountered challenge in screening studies of new<br>chemical entities as well as in formulation design and development. Solubility of some drugs is very less; these<br>drug molecules are often lipophilic and hence dissolution may be a problem in drug absorption from solid oral<br>dosage forms. The increasing interest of the technology of dosage form with natural biopolymers has become<br>the reason for undertaking present investigation on the possibility of modification of guar gum application in<br>the preparation of an oral solid dosage form of a poorly water soluble drug. Present study examines the effect of<br>modified guar gum on the solubility of a poorly water-soluble Nevirapine. Modified guar gum was prepared<br>using heat treatment (110-120oC for 2 hours) method. It was characterized for viscosity and swelling index etc.<br>The physical and co-grinding mixtures of Nevirapine with modified guar gum were prepared in 1:4 drugs to<br>gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study. The studies<br>confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for<br>solubility study and in vitro dissolution studies. The results of present investigation indicated that modified guar<br>gum can be a used for the development of oral dosage form with increased solubility and hence improved<br>dissolution and oral bioavailability of poorly water soluble drug.<br><br></p&gt;}, number={1}, journal={International Journal of Drug Regulatory Affairs}, author={Sarkar, Biresh Kumar and Mishra, Suraj Kumar and Mishra, Suraj Kumar and Gupta, Ajay Krishna and Solanki, Shailendra S}, year={2018}, month={Feb.}, pages={5-9} }