TY - JOUR AU - Mayur S. Jain AU - Sunil R. Bavaskar AU - Shashikant D. Barhate AU - Jintendra D. Fegade PY - 2018/02/11 Y2 - 2024/03/29 TI - SIMULTANEOUS UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CEFADROXIL AND PROBENECID IN TABLET DOSAGE FORM JF - International Journal of Drug Regulatory Affairs JA - Int J Drug Reg Affairs VL - 1 IS - 3 SE - Research DO - 10.22270/ijdra.v1i3.116 UR - https://ijdra.com/index.php/journal/article/view/116 AB - Two methods for simultaneous estimation of Cefadroxil and Probenecid in combined tablet dosage form have been developed. The first UV spectrophotometric method was a determination using the simultaneous equation method at 233 nm and 247 nm. The second UV spectrophotometric method is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 242 nm (Isobestic point) and at 247 nm the maximum absorption of Probenecid . The linearity ranges for Cefadroxil and Probenecid both were 10-60μg/ml respectively. The accuracy of the methods was assessed by recovery studies was found to be 99.43±0.75 and 99.69±0.40 for simultaneous equation method and 99.23±0.34 and 99.56±0.16 for absorption ratio method for Cefadroxil and Probenecid respectively. These methods are simple, accurate and rapid; those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories. ER -