A STUDY ON HEAMPHILUS INFLUANZAE TYPE B DISEASE CAUSING ANTIGENS: AN APPROACH OF EPITOPE PREDICTION, ANTIGENICITY AND IMMUNOGENICITY PREDICTION
Abstract
Vaccines work by mimicking disease agents and stimulating the immune system which in turn builds a defence mechanism against the disease causing agents. Some of the vaccines contain a part of the disease causing agents which are either weakened or dead. Apart from using vaccines only for viral infections, utilizing the same against Cancers both as therapeutic and preventative has captured huge interest. The use of Cancer vaccines in cancer therapies is called immunotherapy which is done either by specific cancer vaccine or universal cancer vaccine which contain tumour antigens that stimulate the immune system which in turn initiate various mechanisms that terminate tumour cells and prevents recurrence of these tumours. Hemophilus influanzae is a disease causing virus & here we have done a brief study about the different antigens of the b strain of Haemophilus influenzae and compare them using various bioinformatics tools to get the most effective antigen of the above mentioned strain.
Downloads
References
2. Verez-Bencomo V, Fernandez-Santana V, Hardy E, Toledo ME, Rodriguez MC, Heynngnezz L, et al. A synthetic conjugate polysaccharide vaccine against Haemophilus influenzae type b. Science. 2004; 305(5683): 522-24.
3. Allan I, Loeb MR, Moxon ER. Limited genetic diversity of Haemophilus influenzae type b. Microb Pathog.1987; 2(2):139-45.
4. Manzalawy EL, Honavar. Immunome Research. 2010; 6(Suppl2):S2.
5. Puri J, Talwar V, Juneja M, Agarwal KN, Gupta HC. Prevalence of antimicrobial resistance among respiratory isolates of Haemophilus influenzae. Indian Pediatr.1999; 36(10): 1029-32.
6. Expanded Programme on Immunization. Immunization schedules in the WHO European Region, 1995. Wkly Epidemiol Rec. 1995; 70:221-8.
7. Murphy TF, Nelson MB, Dudas KC, Mylotte JM, Apicella MA. Identification of a specific epitope of Haemophilus influenzae on a 16,600-dalton outer membrane protein. J Infect Dis. 1985; 152(6):1300–7.
8. Kennedy WA, Chang SJ, Purdy K, LE T, Kilgore PE, Kim JS. et al. Incidence of bacterial meningitis in Asia using enhanced CSF testing: polymerase chain reaction, latex agglutination and culture. Epidemiol. 2007; 135(7):1217- 26.
9. Van Alphen L, Riemens T, Poolman J, Hopman C, Zanen HC. Homogeneity of cell envelope protein subtypes, lipopolysaccharide serotypes, and biotypes among Haemophilus influenzae type b from patients with meningitis in the Netherlands. J Infect Dis. 1983 Jul; 148(1):75-81.
10. Nilsson S, Bengtsson MT, Norberg O. Solid-phase synthesis of a fragment of the capsular polysaccharide of Haemophilus influenzae using H-phosphonate intermediates. J. Carbohydr. Chem. 1992; 11:265-85.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The International Journal of Drug Regulatory affairs require a formal written transfer of copyright from the author(s) for each article published. We therefore ask you to complete and return this form, retaining a copy for your records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication.
I/we have read and agree with the terms and conditions stated Page 2 of this agreement and I/we hereby confirm the transfer of all copyrights in and relating to the above-named manuscript, in all forms and media, now or hereafter known, to the International Journal of Drug Regulatory affairs, effective from the date stated below. I/we acknowledge that the IJDRA is relying on this agreement in publishing the above-named manuscript. However, this agreement will be null and void if the manuscript is not published in the IJDRA.
Download link for COPYRIGHT FORM
