FORMULATION AND DEVELOPMENT OF KETOPROFEN BILAYER TABLETS
Abstract
Aim of present research work was formulation and development of bilayer tablets of Ketoprofen to reduce the side
effects of Ketoprofen and to improve the therapeutic benefits and patients’ compliance to treatment. Bi-layer tablets
of Ketoprofen were prepared by direct compression technique using excipients like MCC, superdisintegrant,
aspartame, colour agent were mixed properly shifted from sieve no 40. Before compression; add talc magnesium
stearate mixed it well. Formulations with optimal properties have been selected to obtain bi-layer tablets of adequate
quality. The in vitro dissolution study of the prepared bilayer tablets showed a controlled release of active drugs over
a period of 24 hours.
Downloads
References
oral solid drug delivery system: a review.” Int. J.
Pharm Sci and Res. 2011; 2: 1108-15.
2. Saravanan V, Revathi R, Meera N. Method
development and validation for the simultaneous
estimation of lycopene and ubidecarenone by RPHPLC
in combined pharmaceutical dosage form.
Journal of Drug Delivery and Therapeutics. 2016;
6(5): 46-51.
3. Abebe A, Akseli I, Sprockel O, Kottala N, and
Cuitino AM. “Review of Bilayer Tablet
Technology.” International. J. Pharmaceutics. 2014;
461:549-58.
4. Dagariya RK, Jat RK. Method development and
validation of Irbesartan chlorthalidone and
Cilnidipine in their combined tablet dosage form by
high performance liquid chromatography. Journal of
Drug Delivery and Therapeutics. 2017; 7(4):88-96.
doi: http://dx.doi.org/10.22270/jddt.v7i4.1471
5. Kumar AP, Pramodaganta, Bhoopathi SG and,
Kulkarni SV. “Current Innovation in Layered Tablet
Technology: Review.” Asian. J. Res pharm. sci.;
2013: 3:189-94.
6. Garg A, Gupta MM. Taste masking and formulation
development & evaluation of mouth dissolving
tablets of levocetrizine dihydrochloride. Journal of
Drug Delivery & Therapeutics. 2013; 3(3):123-130.
7. Momin S, Khan S, Ghadage DM, Yadav AV, Wagh
A. Formulation and evaluation of bilayer tablets of
propranolol hydrochloride. Journal of Drug Delivery
and Therapeutics. 2017; 7(2):50-57.
doi: http://dx.doi.org/10.22270/jddt.v7i2.1399
8. Debajyoti Ray, Amresh K Prusty. Designing and invitro
studies of gastric floating Tablets of Tramadol
hydrochloride. Int J Appl Pharm. 2010; 2(4):12-16.
9. Patel K, Vyas J, Upadhyay U. Formulation and
evaluation of sustained release matrix tablets of
nateglinide. Journal of Drug Delivery and
Therapeutics. 2015; 5(5):19-25.
doi:10.22270/jddt.v5i5.1130
10. Agrawal R. Pharmaceutical processing- a review on
wet granulation technology. IJPFR. 2011; (1):65-83.
The International Journal of Drug Regulatory affairs require a formal written transfer of copyright from the author(s) for each article published. We therefore ask you to complete and return this form, retaining a copy for your records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication.
I/we have read and agree with the terms and conditions stated Page 2 of this agreement and I/we hereby confirm the transfer of all copyrights in and relating to the above-named manuscript, in all forms and media, now or hereafter known, to the International Journal of Drug Regulatory affairs, effective from the date stated below. I/we acknowledge that the IJDRA is relying on this agreement in publishing the above-named manuscript. However, this agreement will be null and void if the manuscript is not published in the IJDRA.
Download link for COPYRIGHT FORM
