FORMULATION, DEVELOPMENT AND OPTIMIZATION OF MODIFIED RELEASING PELLETS OF DRUG CARVEDILOL

  • Abdul Nasir Kurnool Institute of Pharmacy, Shri JJT University, Jhunjhunu (Raj) India.
  • Rakesh Kumar Jat Institute of Pharmacy, Shri JJT University, Jhunjhunu (Raj) India.
  • C Narendra Viswesvarapura Institute of Pharmaceutical Sciences, Bangalore, India.

Abstract

The main objectives of present work was to design and evaluate modified releasing pellets of drug, Carvedilol, in
respect to increase patient compliance and therapeutically benefits. The modified releasing pellets were made by the
sub-coating with sodium bicarbonate and hydroxyl propyl methyl cellulose which was utilized to keep the spheres in
stomach for long time. To get modified release of active pharmaceutical ingredients from the pelletizing process, they
were coated with methacrylic acid co-polymer (Eudragit NE 40D). Hence sodium bicarbonate, hydroxyl propyl
methyl cellulose and eudragit NE 40D are the key ingredients of this dissertation work. Concentration of sodium
bicarbonate, hydroxyl propyl methyl cellulose and eudragit NE 40D in coating suspension was optimized by initial
studies and factorial design. The procedure based optimization analysis also perform to optimize process factors like
product temperature and spraying rate to improve physical parameters and micromeritic characteristics of spheres by
preliminary data.
 

Keywords: Carvedilol, Eudragit, Multiparculate, Thin layer chromatography, High performance liquid chromatography.

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Author Biographies

Abdul Nasir Kurnool, Institute of Pharmacy, Shri JJT University, Jhunjhunu (Raj) India.

Institute of Pharmacy, Shri JJT University, Jhunjhunu (Raj) India.

Rakesh Kumar Jat, Institute of Pharmacy, Shri JJT University, Jhunjhunu (Raj) India.

Institute of Pharmacy, Shri JJT University, Jhunjhunu (Raj) India.

C Narendra, Viswesvarapura Institute of Pharmaceutical Sciences, Bangalore, India.

Viswesvarapura Institute of Pharmaceutical Sciences, Bangalore, India.

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How to Cite
Kurnool, A. N., R. K. Jat, and C. Narendra. “FORMULATION, DEVELOPMENT AND OPTIMIZATION OF MODIFIED RELEASING PELLETS OF DRUG CARVEDILOL”. International Journal of Drug Regulatory Affairs, Vol. 5, no. 4, Dec. 2017, pp. 33-43, doi:10.22270/ijdra.v5i4.208.