FORMULATION, DEVELOPMENT AND OPTIMIZATION OF MODIFIED RELEASING PELLETS OF DRUG CARVEDILOL
The main objectives of present work was to design and evaluate modified releasing pellets of drug, Carvedilol, in
respect to increase patient compliance and therapeutically benefits. The modified releasing pellets were made by the
sub-coating with sodium bicarbonate and hydroxyl propyl methyl cellulose which was utilized to keep the spheres in
stomach for long time. To get modified release of active pharmaceutical ingredients from the pelletizing process, they
were coated with methacrylic acid co-polymer (Eudragit NE 40D). Hence sodium bicarbonate, hydroxyl propyl
methyl cellulose and eudragit NE 40D are the key ingredients of this dissertation work. Concentration of sodium
bicarbonate, hydroxyl propyl methyl cellulose and eudragit NE 40D in coating suspension was optimized by initial
studies and factorial design. The procedure based optimization analysis also perform to optimize process factors like
product temperature and spraying rate to improve physical parameters and micromeritic characteristics of spheres by
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