FORMULATION AND IN-VITRO EVALUATION OF HOLLOW MICROSPHERES OF GLIPIZIDE
Abstract
Present work involves attempts to improve floating time of glipizide by formulation of hollow microspheres
incorporating Glyceryl Monostearate and acryflow. The floating microspheres were evaluated for percentage yield,
drug loading, In-vitro buoyancy behavior as well as in-vitro drug release. The micrometric properties were found to
be good and scanning electron microscopy shows that the microspheres were spherical with smooth surface and a
hallow cavity inside microspheres. The practical yield was found to be in the range of 83.88-90.98% and with a
particle size range of 320-480 μm. The percent entrapment is about 76 % to 91 % which decreased with increase in
HPMC concentration in the formulations. The microspheres with high concentrations of Acrycoat S100 showed
higher buoyancy. The in-vitro release was slow and extended to more than 12 hours which increased with significant
increase in HPMC concentration but decreased in buoyancy character. Release obeys zero order kinetics and the drug
release was diffusion controlled. Hence it can be concluded that the floating microsphere of Glipizide may prolong
drug release thereby improving bioavailability and enhance opportunity of absorption in stomach.
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