FORMULATION AND IN-VITRO EVALUATION OF HOLLOW MICROSPHERES OF GLIPIZIDE

  • Arun Kumar Jaipur School of Pharmacy, Maharaj Vinayak Global University, Jaipur, Rajasthan, India
  • Anil Midda OPJS University, Churu, Rajasthan, India
  • Mahesh Jhanjharia Saroj College of Pharmacy, Lucknow, U.P., India

Abstract

Present work involves attempts to improve floating time of glipizide by formulation of hollow microspheres
incorporating Glyceryl Monostearate and acryflow. The floating microspheres were evaluated for percentage yield,
drug loading, In-vitro buoyancy behavior as well as in-vitro drug release. The micrometric properties were found to
be good and scanning electron microscopy shows that the microspheres were spherical with smooth surface and a
hallow cavity inside microspheres. The practical yield was found to be in the range of 83.88-90.98% and with a
particle size range of 320-480 μm. The percent entrapment is about 76 % to 91 % which decreased with increase in
HPMC concentration in the formulations. The microspheres with high concentrations of Acrycoat S100 showed
higher buoyancy. The in-vitro release was slow and extended to more than 12 hours which increased with significant
increase in HPMC concentration but decreased in buoyancy character. Release obeys zero order kinetics and the drug
release was diffusion controlled. Hence it can be concluded that the floating microsphere of Glipizide may prolong
drug release thereby improving bioavailability and enhance opportunity of absorption in stomach.
 

Keywords: Hollow microspheres, floating time, glipizide, HPMC.

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Author Biographies

Arun Kumar, Jaipur School of Pharmacy, Maharaj Vinayak Global University, Jaipur, Rajasthan, India

Jaipur School of Pharmacy, Maharaj Vinayak Global University, Jaipur, Rajasthan, India

Anil Midda, OPJS University, Churu, Rajasthan, India

OPJS University, Churu, Rajasthan, IndiaUniversity, Jaipur, Rajasthan, India

Mahesh Jhanjharia, Saroj College of Pharmacy, Lucknow, U.P., India

Saroj College of Pharmacy, Lucknow, U.P., India

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How to Cite
Kumar, A., A. Midda, and M. Jhanjharia. “FORMULATION AND IN-VITRO EVALUATION OF HOLLOW MICROSPHERES OF GLIPIZIDE”. International Journal of Drug Regulatory Affairs, Vol. 5, no. 4, Dec. 2017, pp. 68-74, doi:10.22270/ijdra.v5i4.211.