Experience of Health professionals in the implementation of Clinical trials of Traditional Herbal Medicines: A cross-sectional study in Mali

  • Aboubacar SANGHO Faculté de Pharmacie de l'Université des Sciences, des Techniques et des Technologies de Bamako
  • Daniel Dori Drug Development Laboratory, African Center of Excellence for Training, Research and Expertise in Pharmaceutical Sciences (CEA-CFOREM), Sciences and Health Doctoral School, Training and Research Unit in Health Sciences, Joseph KI-ZERBO University, 03 BP 7021 Ouagadougou, Burkina Faso; Pediatric University Hospital Center Charles De Gaulle, 01 BP 1198 Ouagadougou 03, Burkina Faso
  • Kampadilemba Ouoba Drug Development Laboratory, African Center of Excellence for Training, Research and Expertise in Pharmaceutical Sciences (CEA-CFOREM), Sciences and Health Doctoral School, Training and Research Unit in Health Sciences, Joseph KI-ZERBO University, 03 BP 7021 Ouagadougou, Burkina Faso; National Agency for Pharmaceutical Regulation, Ministry of health, 03 BP 7009 Ouagadougou 03, Burkina Faso
  • Oumar Sangho Department of Teaching and Research in Public Health and Specialities, Faculty of Medicine and Odontostomatology, USTTB, Mali
  • Assitan Kaloga Pharmaceutical Sciences Teaching and Research Department, Faculty of Pharmacy, University of Science, Technique and Technology of Bamako (USTTB), Mali; Drug Development Laboratory, African Center of Excellence for Training, Research and Expertise in Pharmaceutical Sciences (CEA-CFOREM), Sciences and Health Doctoral School, Training and Research Unit in Health Sciences, Joseph KI-ZERBO University, 03 BP 7021 Ouagadougou, Burkina Faso
  • Rokia Sanogo Pharmaceutical Sciences Teaching and Research Department, Faculty of Pharmacy, University of Science, Technique and Technology of Bamako (USTTB), Mali; National Research Institute for Traditional Medicine and Pharmacopoeia (INRMPT), Bamako, Mali.
  • Rasmané Semdé Drug Development Laboratory, African Center of Excellence for Training, Research and Expertise in Pharmaceutical Sciences (CEA-CFOREM), Sciences and Health Doctoral School, Training and Research Unit in Health Sciences, Joseph KI-ZERBO University, 03 BP 7021 Ouagadougou, Burkina Faso

Abstract

Objective: The objective of this study was to determine the experience of health professionals in clinical trials of traditional herbal medicines in Mali.


Material and methods: This was a cross-sectional study conducted from June to December 2022 among healthcare professionals in three randomly selected localities: the district of Bamako and the regions of Koulikoro and Sikasso. Data were collected by direct interview using an anonymous questionnaire. The Chi-square (χ2) test was used to assess factors associated with participation in clinical trials of traditional medicines.


Results: The involvement of healthcare professionals in clinical trials of traditional medicines was low (3.5%) and was associated with age (p=0.021). The obstacles to conducting these trials reported by healthcare professionals were lack of funding and failure to take account of the specificities of traditional medicines in clinical trial regulations. Some healthcare professionals suggest ethnomedical evaluation of recipes proposed by traditional practitioners and the use of reverse pharmacology as alternatives.


Conclusion: Research into traditional medicines could be given greater impetus by the long-term funding of clinical trials and by less costly alternatives such as the ethnomedical evaluation of recipes proposed by traditional healers and reverse pharmacology.

Keywords: Traditional herbal medicines (THMs), clinical trials, healthcare professionals, Mali, World Health Organization (WHO), Sampling

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How to Cite
SANGHO, A., D. Dori, K. Ouoba, O. Sangho, A. Kaloga, R. Sanogo, and R. Semdé. “Experience of Health Professionals in the Implementation of Clinical Trials of Traditional Herbal Medicines: A Cross-Sectional Study in Mali”. International Journal of Drug Regulatory Affairs, Vol. 12, no. 2, June 2024, pp. 8-14, doi:10.22270/ijdra.v12i2.659.