TECHNOLOGY DVELOPMENT FOR POLYMER MODIFICATION TO ENHANCE SOLUBILITY OF POORLY SOLUBLE DRUG
Solubilization of poorly soluble drugs is a frequently encountered challenge in screening studies of new
chemical entities as well as in formulation design and development. Solubility of some drugs is very less; these
drug molecules are often lipophilic and hence dissolution may be a problem in drug absorption from solid oral
dosage forms. The increasing interest of the technology of dosage form with natural biopolymers has become
the reason for undertaking present investigation on the possibility of modification of guar gum application in
the preparation of an oral solid dosage form of a poorly water soluble drug. Present study examines the effect of
modified guar gum on the solubility of a poorly water-soluble Nevirapine. Modified guar gum was prepared
using heat treatment (110-120oC for 2 hours) method. It was characterized for viscosity and swelling index etc.
The physical and co-grinding mixtures of Nevirapine with modified guar gum were prepared in 1:4 drugs to
gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study. The studies
confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for
solubility study and in vitro dissolution studies. The results of present investigation indicated that modified guar
gum can be a used for the development of oral dosage form with increased solubility and hence improved
dissolution and oral bioavailability of poorly water soluble drug.
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