• Biresh Kumar Sarkar
  • Suraj Kumar Mishra
  • Suraj Kumar Mishra
  • Ajay Krishna Gupta
  • Shailendra S Solanki


Solubilization of poorly soluble drugs is a frequently encountered challenge in screening studies of new
chemical entities as well as in formulation design and development. Solubility of some drugs is very less; these
drug molecules are often lipophilic and hence dissolution may be a problem in drug absorption from solid oral
dosage forms. The increasing interest of the technology of dosage form with natural biopolymers has become
the reason for undertaking present investigation on the possibility of modification of guar gum application in
the preparation of an oral solid dosage form of a poorly water soluble drug. Present study examines the effect of
modified guar gum on the solubility of a poorly water-soluble Nevirapine. Modified guar gum was prepared
using heat treatment (110-120oC for 2 hours) method. It was characterized for viscosity and swelling index etc.
The physical and co-grinding mixtures of Nevirapine with modified guar gum were prepared in 1:4 drugs to
gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study. The studies
confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for
solubility study and in vitro dissolution studies. The results of present investigation indicated that modified guar
gum can be a used for the development of oral dosage form with increased solubility and hence improved
dissolution and oral bioavailability of poorly water soluble drug.

Keywords: Solubility, bioavailability, guar gum, Nevirapine.


Download data is not yet available.


1. Baveja J. M., Misra A. N., Modified
Guar gum as a Tablet Disintigrant,
Pharmazie, 1997; 52: 856-859.
2. Aulton M. E., Pharmaceutics the
Design and Manufacture of
Pharmaceutics, 3rd ed, 2007; 286.
3. Noyes A. A., Whitney W. R., The
Rate of Solution of Solid Substances
in Their Own Solutions, J Am Chem,
1897; 19: 930-934.
4. Wadke, D.A., Serajuddin, A.T.M.,
Jacobson, H., Preformulation
Testing. In: Lieberman, W.A.,
Lachman, L., Schwartz, J.B. (Eds.),
Pharmaceutical Dosage
Forms:Tablets, Marcel Dekker, New
York, 1989; 1: 1–73.
5. Annex - 8, Proposal to Waive In
Vivo Bioequivalence Requirements
for WHO Model List of Essential
Medicines Immediate-Release, Solid
Oral Dosage Forms WHO Technical
Report Series, 2006; 937: 413.
6. Sreeraj M., In Vitro– In Vivo
Correlation for Nevirapine Extended
Release Tablets, Biopharm. Drug
Dispos, 2009; 30: 542–550.
7. Panchagnula R., Perumal O. P.,
Sarkar M., Solid State
Characterization of Nevirapine,
Indian Journal of Pharmaceutical
Sciences, 2008; 1: 619.
8. Murli Mohan Babu G. V., Prasad C.
H. D. S., Ramana Murthy K. V.,
Evaluation of Modified Gum Karaya
as Carrier for Dissolution
Enhancement of Poorly Water
Soluble Drug Nimodipine. Int J
Pharm, 2002; 234: 1-17.
9. Garzon L. C., Martinez S.,
Temperature Dependence of
Solubility for Licofeloneprofen in
Some Organic and Aqueous
Solvents, Journal of Solution
Chemistry, 2004; 13(11): 1379.
180 Views | 239 Downloads
How to Cite
Sarkar, B. K., S. K. Mishra, S. K. Mishra, A. K. Gupta, and S. S. Solanki. “TECHNOLOGY DVELOPMENT FOR POLYMER MODIFICATION TO ENHANCE SOLUBILITY OF POORLY SOLUBLE DRUG”. International Journal of Drug Regulatory Affairs, Vol. 1, no. 1, Feb. 2018, pp. 5-9, doi:10.22270/ijdra.v1i1.103.