SIMULTANEOUS UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CEFADROXIL AND PROBENECID IN TABLET DOSAGE FORM

  • Mayur S. Jain
  • Sunil R. Bavaskar
  • Shashikant D. Barhate
  • Jintendra D. Fegade

Abstract

Two methods for simultaneous estimation of Cefadroxil and Probenecid in combined tablet dosage form have been developed. The first UV spectrophotometric method was a determination using the simultaneous equation method at 233 nm and 247 nm. The second UV spectrophotometric method is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 242 nm (Isobestic point) and at 247 nm the maximum absorption of Probenecid . The linearity ranges for Cefadroxil and Probenecid both were 10-60μg/ml respectively. The accuracy of the methods was assessed by recovery studies was found to be 99.43±0.75 and 99.69±0.40 for simultaneous equation method and 99.23±0.34 and 99.56±0.16 for absorption ratio method for Cefadroxil and Probenecid respectively. These methods are simple, accurate and rapid; those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.

Keywords: Cefadroxil, Probenecid, Q–analysis spectrophotometric, Simultaneous equation method.

Downloads

Download data is not yet available.

References

1. Cefadroxil. Drug Bank. [Internet] 2013 Feb [cited 2013 Oct 24]. Available from: www.drugbank.ca/drugs/DB01140
2. Shukla R, Patel A, Soni M, Modi V , Jaliwala Y. Quantitative spectrophotometric estimation of Cefadroxil using hydrotropic solubilization technique. Asian journal of pharmaceutics. 2008; 2:146-7.
3. Blanchin MD, Kok WT, Fabre H. New detection modes for the determination of cephalosporins and their decomposition products. Chromatographia. 1987 Dec; 24 (1): 625 – 27.
4. Badawy SS, Abdel‐Gawad FM, Ibrahim MM. Spectrophotometric Studies on Determination of Cefadroxil with Copper(II) and Vanadium(V) in Sulphuric Acid Medium. Anal. Lett. 1993 March; 26 (3): 487-97.
5. Butler D: Wartime tactic doubles power of scarce bird-flu drug. Nature. Pubmed. 2005 Nov 3; 438(7064): 6.
Statistics
231 Views | 270 Downloads
How to Cite
Jain, M. S., S. R. Bavaskar, S. D. Barhate, and J. D. Fegade. “SIMULTANEOUS UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CEFADROXIL AND PROBENECID IN TABLET DOSAGE FORM”. International Journal of Drug Regulatory Affairs, Vol. 1, no. 3, Feb. 2018, pp. 19-23, doi:10.22270/ijdra.v1i3.116.